分类： 医学、药学 >> 中医学与中药学 提交时间： 2024-02-26
摘要： Objective. To study the main differential metabolites of Xihuang Pill (XHP) in rat serum and the mechanism of related pathways of metabolites on breast cancer. Method. Qualitative and quantitative analysis of metabolites in XHP drug serum group and blank serum group by liquid chromatography-mass spectrometry (LC-MS) technology. And using sample correlation heat map and multivariate statistical analysis methods to compare the metabolic differences between the two groups. The metabolites were analyzed by cluster analysis, Variable Importance in Projection (VIP) analysis, Kyoto Encyclopedia of genes and Genomes (KEGG) compound classification and KEGG functional and enrichment topology analysis. Result. LC-MS technology identified a total of 765 metabolites in the XHP drug serum group; a total of 697 metabolites in the blank serum group. VIP analysis screened the top 30 serum differential metabolites that were significantly different between the two groups, such as Abscisic acid, Quillaic acid, 2,2-Bis(4-hydroxyphenyl)-1-propanol, Corey PG-Lactone Diol, (S)-Naproxen and so on. KEGG compound classification showed that most of the metabolites in XHP were classified as phospholipids and amino acids, steroid hormones and carboxylic acids . KEGG functional pathways main involved are Lipid metabolism, Amino acid metabolism, Cancer: overview. KEGG enrichment and topology analysis, mainly involved in steroid hormone biosynthesis pathway and beta-alanine metabolism pathway. Conclusion. The main differential metabolite of XHP in rat serum may be Abscisic acid. XHP may exert its pharmacological effect on breast cancer by regulating steroid hormone biosynthesis pathway to regulate estrogen and progesterone levels and beta-alanine metabolism pathway to induce cancer cell apoptosis.
分类： 光学 >> 量子光学 提交时间： 2023-02-19
摘要： The detection of polarization states of light is essential in photonic and optoelectronic devices. Currently, the polarimeters are usually constructed with the help of waveplates or a comprehensive metasurface, which will inevitably increase the fabrication complexity and unnecessary energy loss. Here, we have successfully demonstrated a self-powered filterless on-chip full-Stokes polarimeter based on a single-layer MoS2/few-layer MoS2 homojunction. Combining the built-in electric field enhanced circular photogalvanic effect with the intrinsic optical anisotropy of MoS2 between in-plane and out-of-plane direction, the device is able to conveniently sense four Stokes parameters of incident light at zero bias without requiring an extra filtering layer, and can function in the wavelength range of 650-690 nm with acceptable average errors. Besides, this homojunction device is easy to integrate with silicon-based chips and could have much smaller sizes than metasurface based polarimeters. Our study thus provides an excellent paradigm for high-performance on-chip filterless polarimeters.
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